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KMID : 0880520220580010006
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Chonnam Medical Journal
2022 Volume.58 No. 1 p.6 ~ p.12
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The Role of Histone Acetylation in Mesenchymal Stem Cell Differentiation
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Jang Su-Jeong
Hwang Jin-Su
Jeong Han-Seong
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Abstract
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The mechanism and action concerning epigenetic modifications, especially that of histone modifications, are not fully understood. However, it is clear that histone modifications play an essential role in several biological processes that are involved in cell proliferation and differentiation. In this article, we focused on how histone acetylation may result in differentiation into mesenchymal stem cells as well as histone acetylation function. Moreover, histone acetylation followed by the action of histone deacetylase inhibitors, which can result in the differentiation of stem cells into other types of cells such as adipocytes, chondrocytes, osteocytes, neurons, and other lineages, were also reviewed.
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KEYWORD
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Mesenchymal Stem Cell, Cell Differentiation, Histone Acetylation, Epigenesis, Genetic
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